Developmental Therapeutics Core

The Developmental Therapeutics Core (DTC) is a key component in preclinical drug development at Northwestern University. The core has facilitated the rapid growth of both basic and clinical cancer research with a focus on the development on new therapeutics and diagnostics by supporting the translational aspects of this research. It provides translational services to clinical investigators interested in moving agents into the clinic who might lack laboratory facilities and/or expertise with in vitro or in-vivo including mouse tumor models. It also provides translational services to basic science investigators who lack expertise in tumor biology (e.g., for chemists synthesizing compounds with anti-tumor activities that lack the training to evaluate these compounds in vitro and in vivo). Finally, the core also investigates novel therapeutic targets and approaches and novel animal tumor models to support the next generation of translation including exploratory Pharmacokinetics and Toxicology of novel compounds. The DTC is prepared to advance the goals of the Northwestern cancer research community in advancing new therapeutics and diagnostics from the benchtop into the clinic.