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Clinical Trials

Gastrointestinal: Colon

A Phase II Study of Pembrolizumab (MK-3475) as Monotherapy in Subjects with Previously Treated Locally Advanced Unresectable or Metastatic (Stage IV) Mismatched Repair Deficient or Microsatellite Instability-High Colorectal Carcinoma (KEYNOTE-164)

To evaluate the ORR per RECIST 1.1 assessed by central imaging vendor of the 200 mg Q3W dose of pembrolizumab in subjects w/ locally advanced unresectable or metastatic MMR deficient or MSI high CRC.

Status: Accepting New Patients
Principal Investigator: Al Benson III

A Phase 1 Open-label, Multicenter Study To Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of an Anti-CTLA-4 Human Monoclonal Antibody (AGEN1884), and to Estimate the Maximum Tolerated Dose in Subjects With Advanced or Refractory Cancer

The purpose of this study is to Evaluate the safety, tolerability, and DLTs of AGEN1884 in advanced or metastatic cancer (solid tumors or lymphoma) including but not limited to carcinoma, sarcoma, malignant glioma, or melanoma

Status: Accepting New Patients
Principal Investigator: Priya Kumthekar

A Phase I, Open-Label, Multiple-Ascending Dose Trial to Investigate the Safety, Tolerability, Pharmacokinetics, Biological and Clinical Activity of Avelumab (MSB0010718C) in Subjects with Metastatic or Locally Advanced Solid Tumors and Expansion to Selected Indications

The research study is testing the study drug MSB0010718C, given in subjects with solid tumors. Additional purposes of the study are to assess side effects of MSB0010718C and to find out whether MSB0010718C has anti-cancer effects. In addition, we would like to find out how MSB0010718C is processed by the body (this is called pharmacokinetic or PK research). We would also like to learn more about the research participant’s disease and the response to the investigational drug by measuring certain “biomarkers”. “Biomarkers” refer to different types of material/markers found in the blood and tumor tissue that are associated with the disease and/or the research participant’s response to the study drug.

Status: Accepting New Patients
Principal Investigator: Halla Nimeiri

Randomized, Double-Blind, Phase II Trial of Vitamin D Supplementation in Participants with Previously Untreated Metastatic Colorectal Cancer (11-436)

The purpose of this study is to compare standard and high dose Vitamin D treatment given in combination with standard treatment for metastatic colorectal cancer (cancer has spread to other areas).

Status: Accepting New Patients
Principal Investigator: Halla Nimeiri

Phase 1/2, Open-Label, Dose-Escalation, Safety and Tolerability Study of INCB054329 in Subjects With Advanced Malignancies

The purpose of this study is to find out how safe and tolerable the study drug INCB054329 is in patients with advanced types of cancer (including solid tumors and blood cancers). This study will mainly answer the following: 1) the maximum dose that can be given to the patient with minimal side effects; 2) the amount of the study drug that enters and leaves the body over time and the effects it has on the body; 3) preliminary evidence of whether or not the drug has any anti-cancer effects.

Status: Accepting New Patients
Principal Investigator: Jason Kaplan

A Randomized Phase II Study of Irinotecan and Cetuximab with or without the Anti-Angiogenic Antibody, Ramucirumab (IMC-1121B), in Advanced, K-ras Wild-type Colorectal Cancer Following Progression on Bevacizumab-Containing Chemotherapy

The purpose of this study is to determine what good or bad effects the drug, ramucirumab, may have and to determine whether it is safe and effective for patients to receive.

Status: Accepting New Patients
Principal Investigator: Al Benson III

A Phase III Clinical Trial Evaluating TheraSphere® in Patients with Metastatic Colorectal Carcinoma of the Liver who have Failed First Line Chemotherapy

The purpose of this study is to see if adding TheraSphere treatment at the beginning of second-line chemotherapy extends survival time and is safe.

Status: Accepting New Patients
Principal Investigator: Mary Mulcahy

A Phase 1 Study Evaluating the Safety, Pharmacology and Preliminary Activity of the Co-Administration of MM-151 and MM-121 in Heregulin Positive Cancer Patients

The study will be done in two parts. In Part 1 of the study, patients with lung, colorectal, or head and neck cancer will receive study drug MM-151 in combination with study drug MM-121. The purpose is to determine a safe dose of MM-151 plus MM-121 combination that does not cause unacceptable side effects. This is also referred to as maximum tolerated dose (MTD). MTD will be determined by evaluating the safety and tolerability of MM-151 when combined with MM-121 at different doses. In Part 2 of the study, only patients who have colorectal cancer will receive study drug MM-151 combined with study drug MM-121. The purpose is to continue to evaluate safety and tolerability of dose found in Part 1 as well as to evaluate response of patient’s body and cancer to this combination of study drugs.

Status: Accepting New Patients
Principal Investigator: Benedito Carneiro

A Randomized Open-Label Pilot Trial to Evaluate the Safety and Efficacy of Repetitive Transcranial Magnetic Stimulation in Cancer Patients with Depression and Anxiety

The purpose of this study is to test the safety and tolerability of left- and right-sided rTMS as a treatment for depression in the cancer population.

Status: Accepting New Patients
Principal Investigator: Mehmet Dokucu

Modular phase II study to link targeted therapy to patients with pathway activated tumors: Module 7 – Ceritinib (LDK378) for patients whose tumors have aberrations in ALK or ROS1

The purpose of this clinical trial is to study if ceritinib is safe and has beneficial effects in people who have different tumor types (cancer), and/or blood malignancies with an ALK or ROS1 activated pathway.

Status: Accepting New Patients
Principal Investigator: Young Chae

Extended Duration Varenicline for Smoking among Cancer Patients: A Clinical Trial

The main purpose of this research study is to compare 12 versus 24 weeks of varenicline treatment, also known as Chantix®, for smoking cessation.

Status: Accepting New Patients
Principal Investigator: Brian Hitsman

A Phase II Trial of Bevacizumab in Patients with Recurrent Solid Tumor Brain Metastases Who Have Failed Whole Brain Radiation Therapy

The purpose of this study is to see what effect bevacizumab, the drug being tested, will have on brain disease from solid tumor cancers. This study will not evaluate the effect of bevacizumab on the systemic solid tumor cancer.

Status: Accepting New Patients
Principal Investigator: Priya Kumthekar

Phase II/III Study of Image-Guided Radiosurgery/SBRT for Localized Spine Metastasis

There are 2 parts to this study (phase II and phase III). The part of the study in which a participant is enrolled depends on the timing of starting in the study. The purpose of the phase II part of the study is to treat the cancer that has spread to a participant's spine, and is causing pain, with image-guided radiosurgery/SBRT. The purpose of phase III is to compare the effects, good and/or bad, of image-guided radiosurgery/SBRT to standard radiation therapy to find out which treatment provides the most rapid pain relief with the least side effects.

Status: Accepting New Patients
Principal Investigator: John Kalapurakal

last updated: Sun - July 24, 2016 - 02:50 PM

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