Clinical Trial RTOG 0631
- Phase II/III Study of Image-Guided Radiosurgery/SBRT for Localized Spine Metastasis
- Principal Investigator
- John Kalapurakal
- Status: Accepting New Patients
- Study Type: Therapeutic, Symptom Management
- Protocol No:.RTOG 0631
- There are 2 parts to this study (phase II and phase III). The part of the study in which a participant is enrolled depends on the timing of starting in the study. The purpose of the phase II part of the study is to treat the cancer that has spread to a participant's spine, and is causing pain, with image-guided radiosurgery/SBRT. The purpose of phase III is to compare the effects, good and/or bad, of image-guided radiosurgery/SBRT to standard radiation therapy to find out which treatment provides the most rapid pain relief with the least side effects.
- Multiple radiation treatments are frequently used to treat pain caused by cancer that has spread to the spine. Image-guided radiosurgery/stereotactic body radiation therapy (SBRT) is a treatment that uses highly focused x-rays to deliver one single high dose on a specific area of the body. Image-guided radiosurgery/SBRT uses special equipment to position the patient and guide the focused radiation beams toward the area to be treated and away from normal tissue. This study will examine how well this treatment relieves spinal pain compared to current standard standard radiation therapy.
Some of the eligibility criteria include:
- Participants must be 18 years old or older.
- Participants must have spine metastasis (cancer that has spread to the spine).
- Participants must be experiencing severe pain for which treatment with radiosurgery is planned.
- Description of Treatment
- There are 2 phases to this study, phase II and phase III. Participants that are enrolled during the phase II portion will have one high dose radiation treatment to the spine (radiosugery/SBRT treatment). This treatment will last about 60 minutes. Phase III of the study includes 2 groups. Participants in group 1 will receive one radiosurgery/SBRT treatment to this spine. This will take 60 minutes. Participants in group 2 will have one treatment of standard radiation, which takes about 5 minutes.
- Sara Duffey
Clinical Research and Education Specialist
Robert H. Lurie Comprehensive Cancer Center
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last updated: 09-Dec-16 07:34 AM
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