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Clinical Trial NRG CC001

Randomized Phase III Trial of Memantine and Whole-Brain Radiotherapy with Or without Hippocampal Avoidance In Patients with Brain Metastases
Principal Investigator
Timothy Kruser
  • Status: Accepting New Patients
  • Study Type: Therapeutic, Treatment
  • Protocol No:.NRG CC001
To determine whether minimizing radiation dose to the hippocampus (a brain structure that is important for memory) during whole-brain radiation can decrease the risk of cognitive side effects after radiation therapy to the brain to using the usual whole-brain radiation plus memantine (a drug that can also reduce cognitive side effects of brain radiation).
The hippocampus is important for memory formation, and rarely is involved by metastatic brain lesions. It is hoped that avoidance of the hippocampus with radiation will decrease the chance of cognitive side effects. However it is possible hippocampal avoidance could have no impact on cognitive side effects and could be associated with lower rates of disease control. This study will allow the researchers to know whether this different approach is better, the same, or worse than the usual approach.
Some of the eligibility criteria include:
  • Participants must be 18 years of age or older.
  • Participants must have pathologically (histologically or cytologically) proven diagnosis of solid tumor malignancy within 5 years prior to registration
Note: This is only a partial list of eligibility criteria. Please contact the Lurie Cancer Center for complete screening information if you are interested in this clinical trial.
Description of Treatment
Group 1 will get the usual whole-brain radiation therapy plus memantine. Group 2 (investigational or “study” group) will get whole-brain radiation therapy using the hippocampal avoidance technique plus memantine.
Clinical Trials Recruitment Nurse
Robert H. Lurie Comprehensive Cancer Center

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last updated: 19-Oct-17 07:47 AM


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