Clinical Trial DRUG CMEK162X2109
- A Phase IB Open-Label, Multi-Center, Dose Escalation and Expansion Study of Orally Administered MEK162 Plus BYl719 in Adult Patients with Selected Advanced Solid Tumors
- Principal Investigator
- Young Chae
- Status: CLOSED
- Study Type: Therapeutic, Treatment
- Protocol No:.DRUG CMEK162X2109
- The main purpose of this study is to see what effect, good and/or bad, MEK162 and BYL719 given together has on certain advanced solid tumors.
- This is a phase 1 study which means the investigational drugs (not yet approved by the Food and Drug Administration [FDA]for use in treating this certain disease)have shown promise in animal testing, but have not yet been given together to humans. MEK162 works by blocking (inside the cell) a pathway that is thought to play a part in tumor cell and new blood vessel growth (which supplies blood and oxygen to the tumor). Phosphatidylinositol 3’- kinase (P13K)is a type of enzyme (protein)that is involved in tumor cell growth and multiplication. In many cancers the P13K pathway is always active. BYL719 is new type of drug that works by blocking the P13K pathway. Laboratory studies have shown that the combination of these 2 drugs can lessen tumor growth.
Some of the eligibility criteria include:
- Participants must be 18 years of age or older.
- Participants must have a certain type of advanced solid tumor. Contact the study team for more detailed information regarding this.
- Description of Treatment
- Both BYL719 and MEK162 are taken orally (by mouth). There are different treatment combinations of these drugs. The study doctor will tell you what amount of BYL719 and MEK162 you will take. All participants will receive treatments in cycles. Each cycle is 28 days. Participants will continue treatment until their study doctor thinks it is in their best interest to stop.
- Clinical Trials Recruitment Nurse
Robert H. Lurie Comprehensive Cancer Center
Find Related Clinical Trials
Browse by Disease Sites
- Gastrointestinal: Colon
- Gastrointestinal: Esophagus
- Gastrointestinal: Pancreas
- Leukemia: Myeloid leukemia
- Gastrointestinal: Rectum
- Gynecological: Ovarian
Other Clinical Trials by Young Chae
- A Phase 1/2, Open-Label, Dose-Escalation/Dose-Expansion, Safety and Tolerability Study of INCB059872 in Subjects With Advanced Malignancies
- A Phase 1 Dose Escalation and Phase 2 Randomized Double-Blind Study of Veliparib in Combination with Carboplatin and Etoposide as a Therapy of Treatment-Naïve Extensive Stage Disease Small Cell Lung Cancer
- SHERLOC: A Phase 2 Study of MM-121 in Combination with Docetaxel versus Docetaxel Alone in Patients with Heregulin Positive, Locally Advanced or Metastatic Non-Small Cell Lung Cancer
- Phase II/III Biomarker-Driven Master Protocol for Second Line Therapy of Squamous Cell Lung Cancer
- Parallel Proof Of Concept Phase 2 Study Of Nivolumab And Metformin Combination Treatment In Advanced Non-Small Cell Lung Cancer With And Without Prior Treatment With PD-1/PD-L1 Inhibitors
- DART: Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors
last updated: 17-Oct-17 02:36 AM
Clinical trial availability changes frequently. Please check this site often for updates or call 312.695.1102 for personal assistance.