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Clinical Trial DRUG GO28754

A Phase II, Multicenter, Single-Arm Study of MPDL3280a in Patients with PD-L1–Positive Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Principal Investigator
Nisha Mohindra
  • Status: CLOSED
  • Study Type: Therapeutic, Treatment
  • Protocol No:.DRUG GO28754
The purpose of this study is to look at the effects, good or bad, of MPDL3280A on patients and their non-small cell lung cancer (NSCLC).
MPDL3280A is an experimental (study) drug, which means that health authorities have not approved MPDL3280A for the treatment of NSCLC. MPDL3280A is an antibody (a protein produced by the body's immune system) that affects the immune system by blocking the programmed cell death-1 ligand 1 (PD-L1) pathway. The PD-L1 pathway is involved in regulating the body’s natural immune response, but tumors can take advantage of this regulation to partially resist or evade the immune system. By blocking the PD L1 pathway, the study drug (MPDL3280A) may help a patient's immune system stop or reverse the growth of tumors.
Some of the eligibility criteria include:
  • Participants must have advanced (stage III or IV) or recurrent (disease that has returned after prior treatment) non-small cell lung cancer.
  • Participants may not have had prior chemotherapy for their advanced or recurrent cancer.
  • Participants must be 18 or older.
Note: This is only a partial list of eligibility criteria. Please contact the Lurie Cancer Center for complete screening information if you are interested in this clinical trial.
Description of Treatment
Participants in this study will receive the study drug by intravenous (IV) infusion on Day 1 of each cycle. Each cycles lasts 3 weeks (21 days). If the tumor does not grow and participants are tolerating the study drug and the other study procedures, participants will continue to receive the study drug for up to 16 cycles or 12 months (whichever comes first).
Clinical Trials Recruitment Nurse
Robert H. Lurie Comprehensive Cancer Center

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last updated: 20-Oct-17 03:31 AM


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