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Clinical Trial ECOG 2511

Title
Phase I and Randomized Phase II Double Blind Clinical Trial of Cisplatin and Etoposide in Combination with Veliparib (ABT-888) or Placebo as Frontline Therapy for Extensive Stage Small Cell Lung Cancer
Principal Investigator
Jyoti Patel
Details
  • Status: Accepting New Patients
  • Study Type: Therapeutic, Treatment
  • Protocol No:.ECOG 2511
Purpose
The purpose of this study is to compare the effects, good and/or bad, of veliparib when combined with the standard commonly-used drugs (cisplatin and etoposide) on patients and their lung cancer.
Overview
This study is for patients who have small cell lung cancer and have not had prior treatment for their cancer. In this study an investigational drug (veliparib) or a placebo (dummy pill) will be given in addition to cisplatin and etoposide. Investigational means that the drug is currently being tested and is not approved for sale in the United States by the Food and Drug Administration (FDA). Cisplatin and etoposide were chosen for this trial because the benefits and risks are well known, and because together they are currently the most effective therapies against small cell lung cancer.
Eligibility
Some of the eligibility criteria include:
  • Participants must have small cell lung cancer.
  • Participants cannot have had prior chemotherapy or biologic therapy for small cell lung cancer.
  • Participants must be 18 or older.
Note: This is only a partial list of eligibility criteria. Please contact the Lurie Cancer Center for complete screening information if you are interested in this clinical trial.
Description of Treatment
Participants will be "randomized" to get either veliparib or placebo. Randomization means participants will be randomly assigned to a treatment based on chance, like a flip of a coin. This is a double-blinded study, which means that neither the participant or the study doctor or the study staff will know which treatment each participant is receiving. In addition to the study drug/placebo, participants in both groups will get cisplatin and etoposide as the standard chemotherapy for small cell lung cancer. Both cisplatin and etoposide will be given by vein (IV). The chemotherapy will be given in 3 week cycles. A total of 4 cycles will be given.
Contact
Sara Duffey
Clinical Research and Education Specialist
Robert H. Lurie Comprehensive Cancer Center
312.695.1102
cancertrials@northwestern.edu

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last updated: 31-Oct-14 08:29 AM

 

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