Clinical Trial ECOG 2810
- Randomized, Double-Blind Phase III Study of Pazopanib vs. Placebo in Patients with Metastatic Renal Cell Carcinoma Who Have No Evidence of Disease Following Metastatectomy
- Principal Investigator
- Timothy Kuzel
- Status: Accepting New Patients
- Study Type: Therapeutic, Treatment
- Protocol No:.ECOG 2810
- The purpose of this study is to see if pazopanib can reduce the risk of renal cell carcinoma recurring (kidney cancer that comes back) after surgical removal of the cancer.
- In cases where metastatic renal cell carcinoma (kidney cancer that spread) was surgically removed (metastatectomy) the follow up plan is observation and then treatment if there is any sign of the cancer returning. The medical community is always looking for ways to improve the standard of care for cancer. Pazopanib (the study drug) is approved by the Food and Drug Administration (FDA) for metastatic renal cell carcinoma. It has not been tested as a follow-up treatment after metastatectomy to see if it would help reduce the risk of the cancer returning in the future. In this study its use is considered experimental.
Some of the eligibility criteria include:
- Participants must be 18 years of age or older.
- Participants must have had a nephrectomy or partial nephrectomy(surgery to remove all or part of the kidney) for renal cell carcinoma.
- Participants must have metastatic renal cell carcinoma and have undergone surgical resection (removal of the cancer) in one or more areas.
- Description of Treatment
- Participants will be randomized (like the flip of a coin) by computer to one of two groups. Both groups will be taking 4 tablets by mouth every day for 52 weeks. Group 1 will receive pazopanib. Group 2 will receive a placebo (a pill that looks the same as the study drug but does not have any medicine).
- Sara Duffey
Clinical Research and Education Specialist
Robert H. Lurie Comprehensive Cancer Center
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- A Phase 1 Open-label Study of Safety and Tolerability of MEDI4736 in Subjects with Metastatic or Unresectable Melanoma in Combination with Dabrafenib and Trametinib or with Trametinib Alone
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- A Randomized Phase II Trial of Sunitinib/Gemcitabine or Sunitinib in Advanced Renal Cell Carcinoma with Sarcomatoid Features
- A Phase II Trial of Dasatinib in Patients with Unresectable Locally Advanced or Stage IV Mucosal, Acral and Solar Melanomas
- A Randomized Phase II Study of Ipilimumab at 3 mg/kg or 10 mg/kg Alone or in Combination with High Dose Interferon-a in Advanced Melanoma
- A Randomized Phase II Study of Sequential Biotherapy with Aflibercept and High Dose IL-2 versus High Dose IL-2 alone in Patients with Inoperable Stage III or Stage IV Melanoma: Efficacy and Biomarker Study
- A Randomized Phase I Dose-Escalation Trial of Carfilzomib with and without Romidepsin in Cutaneous T-Cell Lymphoma
- Phase II Trial of Everolimus or Everolimus plus Paclitaxel as First-line Therapy in Cisplatin-ineligible Patients with Advanced Urothelial Carcinoma (GU10-147)
last updated: 07-Oct-15 02:25 PM
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