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Clinical Trial NCI UC12H05

Title
Phase I/II Investigation of Temsirolimus Plus Lenalidomide in Relapsed Non-Hodgkin Lymphomas
Principal Investigator
Adam M Petrich
Details
  • Status: Accepting New Patients
  • Study Type: Therapeutic, Treatment
  • Protocol No:.NCI UC12H05
Purpose
The purpose of this study is threefold; first (phase I portion) to determine the safe dose of lenalidomide to be used with temsirolimus for the treatment of relapsed lymphomas (disease has come back or did not respond to treatment); second (phase II portion) to determine disease response (good and/or bad) to the study drugs; and third to determine the toxicity and safety of the treatment.
Overview
Treatment for lymphoma can include chemotherapy or radiation. In some cases the disease comes back (recurs) or does not respond (is refractory) to treatment. Relapsed lymphomas are hard to treat with current drugs. Temsirolimus and lenalidomide are approved for use in other cancers but are experimental in their use for treating lymphomas. Both have antitumor effects. Temsirolimus interferes with a protein (mTOR) in the cell that transmits a signal to stimulate cell growth and survival. Temsirolimus may inhibit (stop the function of) the mTOR protein. Lenalidomide is an anti-angiogenesis medicine. Anti-angiogenesis medicines fight cancer by cutting off a tumor’s blood supply, stopping the blood and nutrients it needs to grow. Both drugs may cause the cancer cells to stop growing or die.
Eligibility
Some of the eligibility criteria include:
  • Participants must be 18 years of age or older.
  • Participants must have Hodgkin or non-Hodgkin lymphoma that has been previously treated.
Note: This is only a partial list of eligibility criteria. Please contact the Lurie Cancer Center for complete screening information if you are interested in this clinical trial.
Description of Treatment
Participants will receive temsirolimus weekly intravenously (in the vein) through a small needle. This will take about 30 minutes. In addition, participants will receive lenalidomide, which is a capsule taken by mouth. Participants will continue on the study for up to 52 weeks as long as the treatment is effective (shrinks the lymphoma) or until the doctor decides it is in the participant’s best interest to be taken off the study drugs.
Contact
Sara Duffey
Clinical Research and Education Specialist
Robert H. Lurie Comprehensive Cancer Center
312.695.1102
cancertrials@northwestern.edu

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last updated: 22-Oct-14 10:21 AM

 

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