Xiao Song, PhD
Research Assistant Professor, Neurology
Research Program
Cancer-Focused Research
My research investigates the roles of RNA alternative splicing in brain tumor development, with the goal of developing innovative RNA-based therapies for brain cancer. I focus on several key areas: 1) how tumor cells leverage alternative splicing to generate various protein isoforms that promote tumor formation; 2) how immune cells adapt their splicing landscapes in response to tumor cells; and 3) whether targeting alternative splicing in tumors can generate isoform-derived antigens that convert the immunologically cold tumor microenvironment and elicit an anti-tumor immune response. Additionally, I am interested in establishing human iPSC-derived glioma models and enhancing three-dimensional organoid culture systems to study glioma biology and evaluate anti-glioma therapeutics.