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The Basic Sciences Research Division of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University includes faculty who investigate all aspects of cell function from misappropriated extracellular matrix to nuclear transcription factors, from biomaterials to cutting edge imaging techniques, and from prognostics, diagnostics, to therapeutics.
This Division is led by Tom O'Halloran, PhD.
If you would like more information on the Basic Sciences Research Division, call the Basic Research Initiatives Office at 847.467.0965.
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Investigate the molecular mechanism of posttranscriptional regulation, particular emphasis on mRNA stability including RNAi, translation, & protein turnover.
Investigate the mechanisms of intracellular membrane trafficking.
Investigate the molecular mechanisms of cell fate determination, such as cell cycle progression, cellular senescence and apoptosis.
Investigate various aspects of carcinogenesis using mouse models.
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Determine how cells interact with each other and with surrounding matrix elements, and better understand adhesion-mediated signaling events and the resultant regulation of gene expression.
Investigate the process of matrix assembly and the regulatory pathways that control the activity of proteinases that remodel the tumor stromal microenvironment and thereby modulate invasion, metastasis, and angiogenesis.
Understand the molecular mechanisms that control epithelial-mesenchymal transitions and regulate tumor cell motility and invasiveness.
Elucidate the mechanisms that regulate the formation and integrity of vascular structures, and characterize compounds that inhibit angiogenesis in vitro, in animal models, and in patients.
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Investigate ligand-receptor interactions in model cells.
Characterize molecular signal transduction mechanisms in neoplastic cells.
Study altered cellular response to tumor-derived hormones and growth factors.
Characterize the impact of anticancer therapeutic and chemopreventive agents on signal transduction pathways and derive translational component
of the research activities.
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Study fundamental mechanisms and identify molecular pathways that control growth, differentiation and oncogenesis by physical science methods.
Develop novel diagnostic agents and techniques that facilitate early detection of cancer and that can be coupled with therapy.
Discover & develop new classes of therapeutic agents that exhibit low systemic toxicity & target factors involved in growth & differentiation of neoplastic cells.
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