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Basic Sciences Research Division

Basic Science Research Division - Robert H. Lurie Comprehensive Cancer Center of Northwestern University The Basic Sciences Research Division of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University includes faculty who investigate all aspects of cell function from misappropriated extracellular matrix to nuclear transcription factors, from biomaterials to cutting edge imaging techniques, and from prognostics, diagnostics, to therapeutics.

This Division is led by Kathleen Green, PhD. If you would like more information on the Basic Sciences Research Division, call the Basic Research Initiatives Office at 847.467.0965.

Cancer Cell Biology (CCB) - View Members
  • Investigate the molecular mechanism of gene expression with particular emphasis on genome organization and post-transcriptional regulation, including mRNA stability, RNAi, translation, and protein turnover
  • Investigate the mechanisms of intracellular membrane trafficking
  • Investigate the molecular mechanisms of cell fate determination, such as cell cycle progression, cellular senescence and apoptosis
  • Investigate various aspects of carcinogenesis using mouse models

Tumor Invasion, Metastasis and Angiogenesis (TIMA) - View Members
  • Determine how cells interact with each other and with surrounding matrix elements, and better understand adhesion-mediated signaling events and the resultant regulation of gene expression
  • Investigate the process of matrix assembly and the regulatory pathways that control the activity of proteinases that remodel the tumor stromal microenvironment and thereby modulate invasion, metastasis, and angiogenesis
  • Understand the molecular mechanisms that control epithelial-mesenchymal transitions and regulate tumor cell motility and invasiveness
  • Elucidate the mechanisms that regulate the formation and integrity of vascular structures, and characterize compounds that inhibit angiogenesis in vitro, in animal models, and in patients.

Signal Transduction in Cancer (STIC) - View Members
  • Investigate ligand-receptor interactions in model cells
  • Characterize molecular signal transduction mechanisms in neoplastic cells
  • Characterize the impact of anticancer therapeutic and chemopreventive agents on signal transduction pathways and derive translational component of the research activities

Cancer and Physical Sciences (CAPS) - View Members
  • Study fundamental mechanisms and identify molecular pathways that control growth, differentiation and oncogenesis by physical science methods;
  • Develop novel diagnostic agents and techniques that facilitate early detection of cancer and that can be coupled with therapy;
  • Discover and develop new classes of therapeutic agents that exhibit low systemic toxicity and target factors involved in growth and differentiation of neoplastic cells.