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- Determine how cells interact with each other and with surrounding matrix elements, and better understand adhesion-mediated signaling events and the resultant regulation of gene expression
- Investigate the process of matrix assembly and the regulatory pathways that control the activity of proteinases that remodel the tumor stromal microenvironment and thereby modulate invasion, metastasis, and angiogenesis
- Understand the molecular mechanisms that control epithelial-mesenchymal transitions and regulate tumor cell motility and invasiveness
- Elucidate the mechanisms that regulate the formation and integrity of vascular structures, and characterize compounds that inhibit angiogenesis in vitro, in animal models, and in patients.