Lurie Cancer Center Member
Tsutomu Kume, PhD
Associate Professor, Medicine, Cardiology Division; Feinberg School of Medicine
Tumor Invasion, Metastasis & Angiogenesis
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Current studies include the role of Foxc transcription factors in pathological angiogenesis, and we have published a paper demonstrating that the Foxc2 transcription factor is highly expressed in the tumor vasculature and regulates tumor angiogenesis (Biochem. Biophys. Res. Commun. 392: 201-206, 2010). However, the mechamism(s) underlying the basis for Foxc2 function in tumor growth and angiogenesis remains to be elucidated. Therefoe, we will seek to address this fundamental question. With expertise in angiogenesis, we will also seek to develop therapeutic strategies designed to inhibit tumor angiogenesis.