Lurie Cancer Center Member
Michael C Jewett, PhD
Assistant Professor, Chemical and Biological Engineering; Robert R. McCormick School of Engineering and Applied Science
Cancer and Physical Sciences
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Professor Jewett's research is at the interface of engineering, chemistry, biology, and medicine. His efforts focus on activating and controlling the translation apparatus (the ribosome and associated factors) for producing new classes of materials and personalized medicine drugs. His group focuses on using cell-free systems to understand, harness, and expand the capabilities of natural biological systems without using intact cells. Circumventing genetic regulation and bypassing transport barriers that complicate efforts to transform organisms into cell factories, cell-free systems enable direct access to the inner workings of the cell. This unprecedented level of control and freedom of design has inspired the rapid development of foundations for engineering cell-free systems over the last few years. Previously, his work contributed towards the development of a cost-effective, prokaryotic cell-free protein synthesis system that is now used for making personalized B-cell lymphoma vaccines.Presently, he is looking to develop a cell-free protein synthesis platform for rapid production and screening of cancer vaccines and human antibodies.