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Lurie Cancer Center Member

Guang-Yu Yang

Guang-Yu Yang, MD, PhD

Academic Title:
Professor, Pathology; Feinberg School of Medicine

Member of:
Signal Transduction in Cancer (STIC)
Cancer Prevention (CP)


View Publications Listing

Cancer-Focused Research:

Surgical Pathology
The long-term objective of our research is to study molecular mechanism and chemoprevention of chronic inflammation-driven carcinogenesis. The specific areas of interest are 1) to develop a molecular mimicking model of ulcerative colitis-associated carcinogenesis in rodents, and further to elucidate the role of inflammation-caused and dietary iron-enhanced nitro-oxidative stress and inflammatory mediators in DNA damage, cell proliferation and inflammation-driven carcinogenesis; 2) to study the pathogenesis and molecular biomarkers of pancreatic carcinoma in genetically engineered mouse model and in human; and 3) to develop an efficient strategy on the prevention of chronic inflammation-driven carcinogenesis, particularly interested in dietary nutrients, antioxidants, green tea and inositol compounds and specifically targeted on colorectal, pancreatic, and liver carcinogenesis.