Lurie Cancer Center Member
Sarah E Rice, PhD
Associate Professor, Cell and Molecular Biology; Feinberg School of Medicine
Tumor Invasion, Metastasis & Angiogenesis
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Kinesin motors drive intracellular transport of many different cargoes along microtubules, and they are critical to trafficking in the nervous system as well as cell division. Antimitotic drugs that act on two kinesin motors, Eg5 and CENP-E, are currently in phase I and II clinical trials. Several kinesin motors, including Eg5 and CENP-E, are intrinsically regulated in the cell by their C-terminal tail domains. Our laboratory's work is inspired by the fact that there appear to be multiple, highly effective mechanisms that nature has developed for regulating kinesin motors. Our hope is that once we understand these natural regulation mechanisms, they can be mimicked to develop new and better antimitotic drugs, resulting ultimately in a larger number of treatment options.