Lurie Cancer Center Member
Richard J Miller, PhD
Professor, Pharmacology; Feinberg School of Medicine
Cancer Cell Biology
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Dr. Richard Miller's research is concerned with how receptor activation regulates different types of neural cell functions. This includes the regulation of neuronal survival, development and carcinogenesis. In particular he is interested in the functions and mechanisms of action of G protein coupled receptors, ion channels and intracellular calcium signaling. Recent work has focused on the functions of chemokines and their receptors in the nervous system. His group showed that neural stem cells express a number of chemokine receptors, including the CXCR4 receptor, which acts as a receptor for HIV-1, and that interference with chemokine signaling has several effects on the nervous system. They demonstrated that glioma cells express different types of chemokine receptors and that chemokines can have effects on glial tumor proliferation and infiltration.