Cancer Center Member
David M Engman, MD, PhD
Professor, Microbiology-Immunology; Feinberg School of Medicine
Translational Research in Solid Tumors
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Cancer Focused Research:
Molecular Diagnosis of Cancer and Inherited Diseases. Working with a dedicated team of faculty and medical technologists, the Thorson Goodall Diagnostic Molecular Biology Laboratory delivers state-of-the-art molecular diagnostic testing for hematologic malignancies, solid tumors, inherited diseases and infectious diseases.
Molecular Cell Biology of Tropical Parasitic Diseases. Trypanosomes are single-celled parasites that cause human illnesses such as African sleeping sickness and Chagas' disease. We are interested in organelle biogenesis in these unique eukaryotic organisms, particularly that of the cilium, which is essential for motility, environmental sensing, and development.
Pathogenesis and Treatment of Inflammatory Heart Disease. 20 million Latin Americans are infected with the American trypanosome Trypanosoma cruzi and approximately 30 percent suffer from Chagas' heart disease (CHD). We study the autoimmune pathogenesis of CHD as part of a long-term drug discovery effort to eradicate the parasite and inhibit the autoimmunity.
Keywords: molecular genetics, next generation sequencing, parasitology, heart, autoimmunity, disease, tropical, pathology, microbiology.