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Clinical Trials

Skin: Melanoma

Modular phase II study to link targeted therapy to patients with pathway activated tumors: Module 5 - LDE225 for patients with PTCH1 and SMO mutated tumors

Researchers want to know if LDE225 is safe and has beneficial effects in people who have different tumor types (cancer), and/or blood malignancies with a PTCH1 and/or SMO activated pathway. This pathway is thought to play a role in tumor cell growth as well as in the growth of new blood vessels, which supply the tumor with nutrients and oxygen.

Status: Accepting New Patients
Principal Investigator: Johnson

A Randomized Phase II Study of Sequential Biotherapy with Aflibercept and High Dose IL-2 versus High Dose IL-2 alone in Patients with Inoperable Stage III or Stage IV Melanoma: Efficacy and Biomarker Study

The purpose of this study is to see whether the combination of the two drugs aflibercept and interleukin-2 (IL-2) will help prevent the growth of your cancer. This study is being done to see if giving IL-2 and aflibercept together (in combination) is more effective in treating your cancer (metastatic melanoma) than IL-2 or aflibercept given by themselves. This study is also being done to look at the severity of the side effects caused by this combination treatment.

Status: Accepting New Patients
Principal Investigator: Kuzel

A Randomized Phase II Trial of Ipilimumab with or without Bevacizumab in Patients with Unresectable Stage III or Stage IV Melanoma

The purpose of this research study is to compare the effects, good and/or bad, of ipilimumab or in combination with bevacizumab in treating unresectable advanced melanoma.

Status: Accepting New Patients
Principal Investigator: Kuzel

A Phase 1 Open-label Study of Safety and Tolerability of MEDI4736 in Subjects with Metastatic or Unresectable Melanoma in Combination with Dabrafenib and Trametinib or with Trametinib Alone

The main purpose of this study is to determine the highest dose of MEDI4736 in combination with dabrafenib and trametinib or trametinib alone that is tolerable (does not cause harmful side effects) in research participants with metastatic or unresectable melanoma. The other main purpose of this study is study the safety of MEDI4736 in combination with dabrafenib and trametinib or trametinib alone.

Status: Accepting New Patients
Principal Investigator: Kuzel

Modular Phase II Study to Link Targeted Therapy to Patients with Pathway Activated Tumors: Module 2 - Dovitinib for Patients with Tumor Pathway Activations Inhibited by Dovitinib Including Tumors with Mutations or Translocations of FGFR, PDGFR, VEGF, CKIT, FLT3, CSFR1, TRK and RET

Researchers want to know if dovitinib (TKI258) is safe and has beneficial effects in people who have different tumor types (cancer) and/or blood malignancies whose disease progressed after standard treatment.

Status: Accepting New Patients
Principal Investigator: Johnson

An Open-Label, Dose Escalation, Phase 1, First-in-Human Study of TAK-659 in Adult Patients with Advanced Solid Tumor and Lymphoma Malignancies

Two of the main purposes of this study are to determine the side effects and risks of TAK-659 and the highest dose of TAK-659 that can be given to patients daily without causing side effects and risks that are too severe.

Status: Accepting New Patients
Principal Investigator: Petrich

Extended Duration Varenicline for Smoking among Cancer Patients: A Clinical Trial

The main purpose of this research study is to compare 12 versus 24 weeks of varenicline treatment, also known as Chantix®, for smoking cessation.

Status: Accepting New Patients
Principal Investigator: Hitsman

A Phase II Trial of Dasatinib in Patients with Unresectable Locally Advanced or Stage IV Mucosal, Acral and Solar Melanomas

The purpose of this study is to find out what effects, good and/or bad, dasatinib has on patients and on melanoma cancer.

Status: Accepting New Patients
Principal Investigator: Kuzel

A Phase II Trial of Bevacizumab in Patients with Recurrent Solid Tumor Brain Metastases Who Have Failed Whole Brain Radiation Therapy

The purpose of this study is to see what effect bevacizumab, the drug being tested, will have on brain disease from solid tumor cancers. This study will not evaluate the effect of bevacizumab on the systemic solid tumor cancer.

Status: Accepting New Patients
Principal Investigator: Kumthekar

A Randomized Phase II Study of Ipilimumab at 3 mg/kg or 10 mg/kg Alone or in Combination with High Dose Interferon-a in Advanced Melanoma

The purpose of this study is to compare the good and bad effects of ipilimumab either alone or in combination with interferon alfa-2b on patients and their melanoma.

Status: Accepting New Patients
Principal Investigator: Kuzel

Feasibility and Safety of Minimally Invasive Inguinal Lymph Node Dissection in Patients with Melanoma

The purpose of this research is to study the safety of a new minimally invasive technique to remove the lymph nodes in your groin.

Status: Accepting New Patients
Principal Investigator: Bilimoria

Multicenter Selective Lymphadenectomy for Melanoma Trial II: A Phase III Multicenter Randomized Trial of Sentinel Lymphadenectomy and Complete Lymph Node Dissection versus Sentinel Lymphadenectomy Alone in Cutaneous Melanoma Patients with Molecular or Histopathological Evidence of Metastases in the Sentinel Node

The overall purpose of the research is to find out if melanoma which is metastatic (has spread) to a sentinel lymph node (first lymph node draining that area of skin) can be treated by removing only the sentinel node from a lymph basin (called a sentinel node biopsy), or if all lymph nodes in a lymph basin must be removed (called a complete lymph node dissection).

Status: Accepting New Patients
Principal Investigator: Wayne

Phase II/III Study of Image-Guided Radiosurgery/SBRT for Localized Spine Metastasis

There are 2 parts to this study (phase II and phase III). The part of the study in which a participant is enrolled depends on the timing of starting in the study. The purpose of the phase II part of the study is to treat the cancer that has spread to a participant's spine, and is causing pain, with image-guided radiosurgery/SBRT. The purpose of phase III is to compare the effects, good and/or bad, of image-guided radiosurgery/SBRT to standard radiation therapy to find out which treatment provides the most rapid pain relief with the least side effects.

Status: Accepting New Patients
Principal Investigator: Kalapurakal

last updated: Sun - September 21, 2014 - 05:58 PM

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