Associate Director, Education and Training - John D. Crispino, PhD
John Crispino, PhD, is Associate Professor of Medicine in the Division of Hematology/Oncology at Northwestern University's Feinberg School of Medicine. Dr. Crispino's laboratory studies the mechanisms of vertebrate blood cell development, performing basic research to define the transcription factors and cell cycle regulators that mediate lineage commitment and differentiation of mature blood cells. They also pursue translational studies to define the genetics of hematologic malignancies and to develop novel therapeutics for acute leukemia. Dr. Crispino's research is supported by multiple grants and awards. Most recently, he was awarded a National Institute of Health (NIH) Challenge Grant in Health and Science Research. Dr. Crispino's award is entitled: "Identification of altered molecular signatures of Down syndrome iPS cells." The project's long-term goal is to determine which of the microRNAs, mRNAs or methylation differences that are caused by trisomy 21 (Down Syndrome) contribute to aberrant hematopoiesis and the predisposition to leukemia in infants and children with Down Syndrome.
Dr. Crispino has published over 45 research articles in prestigious peer-review journals, including Nature Genetics, Journal of Experimental Medicine, Journal of Clinical Investigation, PNAS, Molecular and Cellular Biology and Blood. He currently serves on the editorial board of Blood, the Children's Oncology Group Laboratory Review Committee, the Eastern Cooperative Oncology Group Laboratory Review Committee and the American Society of Hematology Subcommittee on Myeloid Neoplasia. He is also the Chair of the Medical Advisory Board of the Leukemia Research Foundation and the Scientific Advisor of the Myeloproliferative Disease Foundation.